Acute Tubular Necrosis (ATN)


Non-immunological cause of failure of the transplanted kidney to function promptly, a form of delayed graft function (DGF). Donor related factors might include low blood pressure, inadequate renal perfusion during CPR or agonal periods, e.g. a victim of trauma.  ATN may follow many hours of storage and resulting ischemic injury after removal from the donor and transplantation into the recipient. May result from unexpected bleeding during the transplant procedure or a renal biopsy. More common with deceased donor kidneys. Prognosis: recovery of renal function averages six weeks.  May be more common in recipients of kidneys from deceased donors after cardiac death.

UCDavis Health System, Transplant Center (2015). Potential complications after transplant surgery. Sacramento: Author. Retrieved from:

Ounissi, M, Gargah, T., Barbouch, S., Boubaker, K., Cherif, M., Bacha, M.M., Kheder, A. (2012). Acute tubular necrosis in kidney transplantation. Tunis Med, 90:6, 463-7. Retrieved from:



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