Progressive loss of renal function, often associated with proteinuria and hypertension. Risk factors fall into two categories: acute and chronic injury. Rejection as well as donor factors (preservation or reperfusion injury) are possible contributors. Chronic injury may result from such factors as poorly controlled blood pressure, diabetes, dyslipidemia and long term effects of immunosuppressive therapy. Pathology is non-specific and involves a progressive vasculopathy.
Weir, M.R. (n.d.). Chronic allograft nephropathy: Slide presentation. Strategies to reduce nephrotoxic load in renal transplant recipients. Retrieved from: http://www.medscape.org/viewarticle/416552_2