One of the most common malignancies, also associated with Epstein-Barr virus (EBV) (see also Epstein-Barr virus). PTLD may present as a localized or disseminated disease post transplant. Aggressive immunosuppression increases the risk and is associated with earlier disease development. Tumors can be aggressive, progressive and potentially . Presenting symptoms may include fever, lymphadenopathy, gastrointestinal symptoms with possible obstruction, infectious syndrome (may be fulminant), pulmonary symptoms, central nervous system (CNS) symptoms, weight loss, and decline in renal function. Initial intervention may include reduction of immunosuppression however declining renal function may result.
Garfin, P.M. (2015). Posttransplant lymphoproliferative disease. Medscape, Drugs & Diseases. Retrieved from: http://emedicine.medscape.com/article/431364-overview